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On the role of cortex-basal ganglia interactions for category learning: A neuro-computational approach

In addition to the prefrontal cortex (PFC), the basal ganglia (BG) have been increasingly often reported to play a fundamental role in category learning, but the systems-level circuits of how both interact remain to be explored. We developed a novel …

Sustainable computational science: the ReScience initiative

Computer science offers a large set of tools for prototyping, writing, running, testing, validating, sharing and reproducing results; however, computational science lags behind. In the best case, authors may provide their source code as a compressed …

Predictive Place-Cell Sequences for Goal-Finding Emerge from Goal Memory and the Cognitive Map: A Computational Model

Hippocampal place-cell sequences observed during awake immobility often represent previous experience, suggesting a role in memory processes. However, recent reports of goals being overrepresented in sequential activity suggest a role in short-term …

[Re] Robust timing and motor patterns by taming chaos in recurrent neural networks

A reference implementation of: Laje, R. and Buonomano, D.V. (2013). Robust timing and motor patterns by taming chaos in recurrent neural networks. Nat Neurosci. 16(7) pp 925-33 doi://10.1038/nn.3405

ANNarchy: a code generation approach to neural simulations on parallel hardware

Many modern neural simulators focus on the simulation of networks of spiking neurons on parallel hardware. Another important framework in computational neuroscience, rate-coded neural networks, is mostly difficult or impossible to implement using …

Timing and expectation of reward: a neuro-computational model of the afferents to the ventral tegmental area

Neural activity in dopaminergic areas such as the ventral tegmental area is influenced by timing processes, in particular by the temporal expectation of rewards during Pavlovian conditioning. Receipt of a reward at the expected time allows to compute …

Dysfunctional and compensatory synaptic plasticity in Parkinson's disease

In Parkinson's disease, a loss of dopamine neurons causes severe motor impairments. These motor impairments have long been thought to result exclusively from immediate effects of dopamine loss on neuronal firing in basal ganglia, causing imbalances …

Comparison of GPU- and CPU-implementations of mean-firing rate neural networks on parallel hardware

Modern parallel hardware such as multi-core processors (CPUs) and graphics processing units (GPUs) have a high computational power which can be greatly beneficial to the simulation of large-scale neural networks. Over the past years, a number of …

Working memory and response selection: A computational account of interactions among cortico-basalganglio-thalamic loops

Cortico-basalganglio-thalamic loops are involved in both cognitive processes and motor control. We present a biologically meaningful computational model of how these loops contribute to the organization of working memory and the development of …

A Neuroscientific View on the Role of Emotions in Behaving Cognitive Agents

While classical theories systematically opposed emotion and cognition, suggesting that emotions perturbed the normal functioning of the rational thought, recent progress in neuroscience highlights on the contrary that emotional processes are at the …